Past Webinars

2021

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November 17: Seminar Series #3

More than a pretty picture: Advances in Quantitative Digital Pathology

Presenter: Charles W. Frevert, DVM, ScD, University of Washington at South Lake Union

Description: Advances in the research pathology laboratory have increased our ability to efficiently generate high-quality digital images on the expression and accumulation of mRNA, proteins, carbohydrates, signaling pathways, cells, and structures in healthy and diseased tissues. Quantitative digital pathology allows us to analyze these digital images to obtain objective, quantitative, and reproducible data suitable for statistical analysis. This webinar aims to provide an overview of the critical information required to analyze tissues stained using histochemistry, immunohistochemistry, or in situ hybridization.

 

October 27: Seminar Series #2The Importance of Preanalytics when Performing Immunohistochemistry

 Presenter: Stephen Hewitt, M.D., Ph.D., Center for Cancer Research, National Cancer Institute, Editor-in-Chief of The Journal of Histochemistry and Cytochemistry

Description: The quality of any assay is dependent on the quality of the specimen and reagents used to perform the assay. The Pre-analytic variable of cellular and tissue specimens have been historically under-appreciated. The competition of histomorphology versus biomolecular integrity result in complex decisions for the researcher. Dr. Hewitt will discuss the basic principles of pre-analytic quality, approaches to determining if a specimen is fit for purpose and common pitfalls based on inadequate specimen preservation.


 

October 13: Seminar Series #1 - Fundamentals of Microscopy: The Need for Contrast

Presenter: Paul Goodwin, Ph.D., Past-President, The Histochemical Society and Science Director, Cytiva

Description: The light microscope is one of the most ubiquitous instruments in a research laboratory yet most user lack a basic understanding of the instrument. In this lecture, Paul Goodwin will cover the basics requirements for microscopy (magnification, resolution, and contrast) and how those requirements are addressed with a special emphasis on contrast. The lecture will finish with a description of histochemistry and immunohistochemistry as ways of generating contrast with molecular specificity.


August 11: Intravital imaging to visualize age induced vasculo -epithelial changes in the liver

Featured Speaker: Tirthadipa Pradhan-Sundd, PhD, University of Pittsburgh School of Medicine

 


July 14: Harnessing histochemical approaches to reveal novel mechanisms of ovarian aging

Featured Speakers: Francesca Duncan, PhD,
 Farners Amargant i Riera, PhD and Elnur Babyev, MD, Northwestern University

 


 June 9: Tumor microenvironment multiplex immunofluorescence: an illustration of our workflow concept

Featured Speaker: Svetomir Markovic, M.D., Ph.D., Mayo Clinic
Additional Speakers: Rachel Maus PhD; and Alexey Leontovich; PhD

May 12: The Role of Myosin Vb in Maintaining Epithelial Polarity and Homeostasis

HCS 2021 New Investigator Awardee

Amy C. Engevik, Medical University of South Carolina


 April 14: Epigenetic control of vascular homeostasis and smooth muscle function

Featured Speaker: Delphine Gomez, PhD, University of Pittsburgh

February 24: Implicit Bias

An Uncomfortable Truth: Implicit Bias
Edwin J. Barea-Rodriguez, Ph.D. 
Breaking the Mold: Targeting Strategies Against Implicit Bias in Academia
Ann Caroline Fisher, M.D.

February 17: Host-proteoglycans as entry portals for ancient and emerging viruses

Invited Speaker: Sean Whelan, Department of Molecular Microbiology, Washington University in Saint Louis

 


 2020

 December 16: Inflammation and Heart Disease

Longitudinal In Vivo Atherosclerotic Disease Development in The apoE Deficient Zucker Rat
Roberto Mota Alvidrez, University of North Carolina at Chapel Hill
Histopathological Characterization of COVID-19-associated Cardiac Injury
Paul Hanson, University of British Columbia
SOCS3 limits pro-inflammatory signature in septic endothelium
Ramon Bossardi Ramos, Albany Medical College

November 18: Directions from the Extracellular Matrix 

Chaired by Liliana Schaefer, Allgemeine Pharmakologie und Toxikologie,
Division Nephropharmakologie, Klinikum der Goethe Universität

 

Preserved extracellular matrix in non-enzymatically detached cultured keratinocyte
sheets bolsters the healing effects on grafted burn wounds
Suzan Alharbi, University of Texas Medical Branch, Galveston, Texas,
and  King Abdulaziz University, Jeddah, Saudi Arabia    
Regulation of Intestinal Epithelial Intercellular Adhesion and Barrier Function by Desmosomal Cadherin Desmocollin-2
Arturo Raya-Sandino, University of Michigan Medical School     
The Role of the Actin-Binding Protein Cortactin in the Onset and Development of Sepsis
Nathaniel Lartey, CINVESTAV-IPN

 October 21: Liver Biology and Disease Pathogenesis

Chaired by Sofia de Oliveira,
Albert Einstein College of Medicine, Marion Bessin Liver Research Center,Einstein-Mount Sinai Diabetes Research Center

Hepatic crisis in Sickle cell Anemia
Tirthadipa Pradhan-Sundd, University of Pittsburgh
Determining the effects of Wnt signaling in the alleviation of cholestasis via the promotion of hepatocyte transdifferentiation
Karis Kosar, University of Pittsburgh
The Prolyl Isomerase PIN1 Impairs Methionine Adenosyltransferase α1 Mitochondrial Targeting in Alcoholic Liver Disease
Lucia Barbier Torres, Cedars-Sinai Medical Center

If you missed any of these events and would like the recording, let us know!  Email HCS.